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Metabolism and immunity in breast cancer

Deyu Zhang, Xiaojie Xu, Qinong Ye

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 178-207 doi: 10.1007/s11684-020-0793-6

Abstract: Breast cancer is one of the most common malignancies that seriously threaten women’s health.represent the two main fascinating characteristics of cancer and facilitate cancer cell proliferationBreast cancer cells generate energy through increased glucose metabolism.Lipid metabolism contributes to biological signal pathways and forms cell membranes except energy generationHere, we review the recent findings related to abnormal metabolism and immune characteristics, regulatory

Keywords： breast cancer     metabolism     immunity     cancer stem cells    

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The development and benefits of metformin in various diseases

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 388-431 doi: 10.1007/s11684-023-0998-6

Abstract: summarized the benefits of metformin in four types of diseases, including metabolic associated diseases, cancer

Keywords： metformin     metabolism     cancer     aging     neurological disorder    

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The MYC transcription factor network: balancing metabolism, proliferation and oncogenesis

Patrick A. Carroll, Brian W. Freie, Haritha Mathsyaraja, Robert N. Eisenman

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 412-425 doi: 10.1007/s11684-018-0650-z

Abstract: We suggest that these network interactions serve to modulate growth and metabolism at the transcriptional

Keywords： network     transcription     cancer     MYC     MAX     MLX    

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Potential of electron transfer and its application in dictating routes of biochemical processes associated with metabolic reprogramming

Frontiers of Medicine 2021, Volume 15, Issue 5,   Pages 679-692 doi: 10.1007/s11684-021-0866-1

Abstract: addiction to glutamine, and increased de-novo lipid synthesis, extensively occurs in proliferating cancerby examining the net changes of the PET values associated with the biochemical pathways in anaerobic metabolismSome interesting properties of PET in cancer cells were also discussed, and the model was extended toEnabling electron transfer could drive metabolic reprogramming in cancer metabolism.on electron transfer could guide the treatment strategies of tumors and future studies on cellular metabolism

Keywords： metabolic reprogramming     potential of electron transfer     cell proliferation     aerobic glycolysis     cancermetabolism    

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Proteins moonlighting in tumor metabolism and epigenetics

Lei Lv, Qunying Lei

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 383-403 doi: 10.1007/s11684-020-0818-1

Abstract: Cancer development is a complicated process controlled by the interplay of multiple signaling pathwaysHigh plasticity in using diverse nutrients to adapt to metabolic stress is one of the hallmarks of cancerTo respond to nutrient stress and to meet the requirements for rapid cell proliferation, cancer cellsThe signal−moonlighting protein−metabolism axis facilitates the adaptation of tumor cells under varyingenvironment conditions and can be therapeutically targeted for cancer treatment.

Keywords： moonlighting function     tumor metabolism     epigenetics    

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Vanadium metabolism investigation using substance flow and scenario analysis

Fangfang ZHANG, Huiquan LI, Bo CHEN, Xue GUAN, Yi ZHANG

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 2,   Pages 256-266 doi: 10.1007/s11783-013-0585-1

Abstract: Vanadium is a vital strategic resource, and vanadium metabolism is an important part of the nationalThis study conducts accounting and scenario analysis on the life cycle of vanadium metabolism in ChinaA scenario analysis was conducted to analyze the future developmental trend of vanadium metabolism in

Keywords： metabolism     vanadium industry     substance flow analysis     scenario analysis    

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Insulin resistance and the metabolism of branched-chain amino acids

Jingyi Lu, Guoxiang Xie, Weiping Jia, Wei Jia

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 53-59 doi: 10.1007/s11684-013-0255-5

Abstract: particularly responsive to the inhibitory insulin action on amino acid release by skeletal muscle and their metabolism

Keywords： branched-chain amino acids     leucine     isoleucine     valine     insulin resistance    

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Research progress on FASN and MGLL in the regulation of abnormal lipid metabolism and the relationship

Jingyue Zhang, Yawen Song, Qianqian Shi, Li Fu

Frontiers of Medicine 2021, Volume 15, Issue 5,   Pages 649-656 doi: 10.1007/s11684-021-0830-0

Abstract: Tumorigenesis involves metabolic reprogramming and abnormal lipid metabolism, which is manifested byBoth enzymes play an important role in lipid metabolism and are associated with tumor-related signalingarticle introduces the structures and functions of FASN and MGLL, their relationship with abnormal lipid metabolism

Keywords： FASN     MGLL     lipid metabolism     tumor invasion     metastasis    

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Anaerobic ammonia oxidizing bacteria: ecological distribution, metabolism, and microbial interactions

Dawen Gao, Xiaolong Wang, Hong Liang, Qihang Wei, Yuan Dou, Longwei Li

Frontiers of Environmental Science & Engineering 2018, Volume 12, Issue 3, doi: 10.1007/s11783-018-1035-x

Abstract: Anammox (ANaerobic AMMonia OXidation) is a newly discovered pathway in the nitrogen cycle. This discovery has increased our knowledge of the global nitrogen cycle and triggered intense interest for anammox-based applications. Anammox bacteria are almost ubiquitous in the suboxic zones of almost all types of natural ecosystems and contribute significant to the global total nitrogen loss. In this paper, their ecological distributions and contributions to the nitrogen loss in marine, wetland, terrestrial ecosystems, and even extreme environments were reviewed. The unique metabolic mechanism of anammox bacteria was well described, including the particular cellular structures and genome compositions, which indicate the special evolutionary status of anammox bacteria. Finally, the ecological interactions among anammox bacteria and other organisms were discussed based on substrate availability and spatial organizations. This review attempts to summarize the fundamental understanding of anammox, provide an up-to-date summary of the knowledge of the overall anammox status, and propose future prospects for anammox. Based on novel findings, the metagenome has become a powerful tool for the genomic analysis of communities containing anammox bacteria; the metabolic diversity and biogeochemistry in the global nitrogen budget require more comprehensive studies.

Keywords： Anammox     Metabolism     Metagenome     Ecological distribution     Microbial interactions    

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Dynamic simulation of urban water metabolism under water environmental carrying capacity restrictions

Weihua ZENG,Bo WU,Ying CHAI

Frontiers of Environmental Science & Engineering 2016, Volume 10, Issue 1,   Pages 114-128 doi: 10.1007/s11783-014-0669-6

Abstract: A revised concept for urban water metabolism (UWM) is presented in this study to address the inadequaciescan be analyzed to increase the water environmental carrying capacity (WECC) of the new urban water metabolism

Keywords： urban water metabolism system (UWMS)     system dynamic simulation     water environmental carrying capacity    

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Expression profiles of genes and enzymes related to ascorbic acid metabolism in fruits of

Yingying CHEN,Zhihui ZHAO,Jin ZHAO,Mengjun LIU

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 2,   Pages 131-136 doi: 10.15302/J-FASE-2016096

Abstract: The accumulation of AsA, the expression patterns of the nine genes related to AsA metabolism as well

Keywords： Chinese jujube     ascorbic acid     metabolism     gene     enzyme    

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Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 942-942 doi: 10.1007/s11684-021-0876-z

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GDF15 negatively regulates chemosensitivity via TGFBR2-AKT pathway-dependent metabolism in esophageal

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 119-131 doi: 10.1007/s11684-022-0949-7

Abstract: Metabolomics showed that GDF15 could alter cellular metabolism and enhance the expression of UGT1A.

Keywords： GDF15     esophageal squamous cell carcinoma     chemoresistance     cellular metabolism     TGFBR2     AKT    

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Zooming in and out of ferroptosis in human disease

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 173-206 doi: 10.1007/s11684-023-0992-z

Abstract: Ferroptosis is defined as an iron-dependent regulated form of cell death driven by lipid peroxidation. In the past decade, it has been implicated in the pathogenesis of various diseases that together involve almost every organ of the body, including various cancers, neurodegenerative diseases, cardiovascular diseases, lung diseases, liver diseases, kidney diseases, endocrine metabolic diseases, iron-overload-related diseases, orthopedic diseases and autoimmune diseases. Understanding the underlying molecular mechanisms of ferroptosis and its regulatory pathways could provide additional strategies for the management of these disease conditions. Indeed, there are an expanding number of studies suggesting that ferroptosis serves as a bona-fide target for the prevention and treatment of these diseases in relevant pre-clinical models. In this review, we summarize the progress in the research into ferroptosis and its regulatory mechanisms in human disease, while providing evidence in support of ferroptosis as a target for the treatment of these diseases. We also discuss our perspectives on the future directions in the targeting of ferroptosis in human disease.

Keywords： ferroptosis     human disease     iron metabolism     lipid peroxidation     antioxidation    

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Title Author Date Type Operation

Metabolism and immunity in breast cancer

Deyu Zhang, Xiaojie Xu, Qinong Ye

Journal Article

The development and benefits of metformin in various diseases

Journal Article

The MYC transcription factor network: balancing metabolism, proliferation and oncogenesis

Patrick A. Carroll, Brian W. Freie, Haritha Mathsyaraja, Robert N. Eisenman

Journal Article

Potential of electron transfer and its application in dictating routes of biochemical processes associated with metabolic reprogramming

Journal Article

Proteins moonlighting in tumor metabolism and epigenetics

Lei Lv, Qunying Lei

Journal Article

Huang Jiaoti: Amino Acid Metabolism in Therapeutic Failure and Disease Progression of Prostate Cancer

22 Apr 2021

Conference Videos

Vanadium metabolism investigation using substance flow and scenario analysis

Fangfang ZHANG, Huiquan LI, Bo CHEN, Xue GUAN, Yi ZHANG

Journal Article

Insulin resistance and the metabolism of branched-chain amino acids

Jingyi Lu, Guoxiang Xie, Weiping Jia, Wei Jia

Journal Article

Research progress on FASN and MGLL in the regulation of abnormal lipid metabolism and the relationship

Jingyue Zhang, Yawen Song, Qianqian Shi, Li Fu

Journal Article

Anaerobic ammonia oxidizing bacteria: ecological distribution, metabolism, and microbial interactions

Dawen Gao, Xiaolong Wang, Hong Liang, Qihang Wei, Yuan Dou, Longwei Li

Journal Article

Dynamic simulation of urban water metabolism under water environmental carrying capacity restrictions

Weihua ZENG,Bo WU,Ying CHAI

Journal Article

Expression profiles of genes and enzymes related to ascorbic acid metabolism in fruits of

Yingying CHEN,Zhihui ZHAO,Jin ZHAO,Mengjun LIU

Journal Article

Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Journal Article

GDF15 negatively regulates chemosensitivity via TGFBR2-AKT pathway-dependent metabolism in esophageal

Journal Article

Zooming in and out of ferroptosis in human disease

Journal Article